Spectrum Of Activity
Suspected or confirmed anaerobic infections including:
Central nervous system
Clostridium difficile - severe infection IV metronidazole + oral vancomycin.
Also used in:
Assess for peripheral/optic neuropathy with prolonged therapy (>6wks) or if symptoms develop.
GI symptoms common - Especially nausea/vomiting and metallic taste
Peripheral/optic neuropathy with extended therapy
Disulfiram-like reaction (severe vomiting)
Rare neurotoxicity including aseptic meningitis and encephalopathy
Ethanol - Disulfiram-like reaction
Increases levels of:
Bacterial, protozoal and ameobic DNA is fragmented by reactive nitroso-imidazole radicals.
Per IDSA guidelines, no longer recommended as first line treatment for C. difficile associated diarrhea. Oral vancomycin preferred.
Antimicrobial class: Nitroimidazole
Average serum half life: 8-10 hours
Biliary penetration: Therapeutic
CSF penetration: Therapeutic
Lung penetration: Therapeutic