Antimicrobials
Piperacillin-Tazobactam

Piperacillin-Tazobactam

Medium
N/A
$8-15/day

Dosing

General Information

  • Broad spectrum agent with anti-pseudomonal activity.
  • Used for severe infections with risk factors for more resistant organisms including:
    • Pneumonia
    • Intra-abdominal/hepatobiliary
    • UTI
    • Polymicrobial skin and soft tissue infection
    • Febrile neutropenia

Long term: weekly CBC, CMP

  • Allergy/rash (immediate or delayed)
  • Cytopenias- esp. thrombocytopenia
  • Eosinophilia
  • Interstitial nephritis
  • Abnormal liver enzymes
  • Diarrhea/loose stools

Incr. levels of methotrexate

Tends to have higher GI toxicity with high doses in pediatric patients

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic