Antimicrobials
Levofloxacin

Levofloxacin

High
Excellent
PO:<$1 IV: $2-$3

Dosing

General Information

FDA warns against use in the following scenarios: uncomplicated urinary tract infection, acute bacterial exacerbation of chronic bronchitis, and acute bacterial sinusitis.

  • Lower respiratory infection (CAP, HAP)
  • Intraabdominal infection (+metronidazole)

Monitor QTc in patients with increased risk

Legionella pneumonia

  • QTc prolongation
  • Dysglycemia
  • Aortic dissection
  • Aortic aneurysm
  • Rash
  • Tendinopathy and rupture
  • Peripheral neuropathy
  • GI upset
  • Weakness exacerbation in myasthenia gravis
  • CNS toxicity including confusion, insomnia, psychosis - especially in elderly patients
  • Aortic dissections or ruptures
  • MULTIPLE BLACK BOX WARNINGS BY FDA
  • Other QTc prolonging agents
  • Divalent cations - Decreased absorption
  • Warfarin - Increased INR

Due to reduced Pseudomonas aeruginosa susceptibility to quinolones at Billings Clinic, double covering by adding a quinolone to cefepime/piperacillin-tazobactam is not recommended.

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 7 hours

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic