Antimicrobials
Doxycycline

Doxycycline

Low
Excellent
PO: <$1/day IV: ~$35/day

Spectrum of Activity

Dosing

General Information

  • Skin and soft tissue infection
  • Community acquired pneumonia
  • Malaria prophylaxis
  • Zoonoses
  • Methicillin resistant staphylococcus aureus infections
  • GI upset and erosive esophagitis
  • Photosensitivity rash
  • Teeth staining
  • Divalent cations - decreased absorption
  • Increased digoxin levels
  • Increased INR with warfarin
  • Some anticonvulsants can decrease doxycycline levels

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 18 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic

No renal adjustment required