Antimicrobials
Norfloxacin

Norfloxacin

Restricted

High
Moderate

Spectrum of Activity

Dosing

General Information

Prophylaxis of spontaneous bacterial peritonitis.

Uncomplicated UTI.

Monitor QTc in patients with increased risk

  • QTc prolongation
  • Dysglycemia
  • Rash
  • Tendinopathy and rupture
  • GI upset
  • Weakness exacerbation in myasthenia gravis
  • CNS toxicity including confusion, psychosis

Other QTc prolonging agents.

Divalent cations - Decreased absoprtion.

Methadone - Increased seizures.

Thyroid replacement - Decreases T.

Warfarin - Increased INR.

Nonformulary Use ciprofloxacin instead for SBP prophylaxis

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Urine penetration: Therapeutic