Antimicrobials
Fosfomycin

Fosfomycin

Restricted

Low
Moderate
$74/dose

Spectrum of Activity

Dosing

General Information

Treatment of pyelonephritis

Urinary Tract Infection, especially involving resistant organisms such as ESBL producing organisms

Off label - Prostatitis (ID consultation recommended)

  • GI upset, especially diarrhea
  • Headache
  • Eosinophilia, neutropenia
  • Hypokalemia

No significant interactions

Recommended to reserve for resistant organisms such as ESBL or VRE as other treatment options are available for susceptible organisms.

Recommended to use 3 dose treatment series over single use.

Inpatient - restricted to Infectious Diseases.

Antimicrobial class: Phosphonic acid derivative

Pregnancy category: B

Average serum half life: 6 hours

Urine penetration: Therapeutic