General Spectrum of Activity
Monitor QTc in patients with increased risk
Prolongation of QTc interval. Association with increased cardiovascular mortality in observational studies.
Prolonged half life may contribute to macrolide resistance
Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing - e.g. Salmonella species.
Antimicrobial class: Macrolide
Pregnancy category: B
Average serum half life: 68 hours
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Poor
No renal adjustment required