Antimicrobials
Azithromycin

Azithromycin

Medium
Excellent
PO:<$1/day IV: $2.50/day

Spectrum of Activity

Dosing

General Information

  • Community acquired pneumonia - in adjunct with beta-lactam
  • Pertussis
  • Gonorrhea/Chlamydia infections (in addition to IM ceftriaxone 250 mg)
  • Mycobacterial infections
  • Mycobacterium avium complex (MAC) prophylaxis in HIV patients

Monitor QTc in patients with increased risk

Prolongation of QTc interval. Association with increased cardiovascular mortality in observational studies.

Prolonged half life may contribute to macrolide resistance

  • Other drugs that prolong QTc
  • Increases cyclosporine levels
  • May increase digoxin levels

Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing - e.g. Salmonella species.

Antimicrobial class: Macrolide

Pregnancy category: B

Average serum half life: 68 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor

No renal adjustment required