Antimicrobials
Voriconazole

Voriconazole

Restricted

Low
Excellent
PO: $5-10/day IV: $60-70/day

Spectrum of Activity

Dosing

General Information

Antifungal prophylaxis in immunocompromised patients where mould coverage is required

Aspergillus infections

Therapeutic drug monitoring may be helpful to ensure adequate concentrations and exclude toxicity (Discuss with ID). Send voriconazole trough level 30 min before dose is due. Nonlinear kinetics.

QTc interval in patients at elevated risk.

Always double check drug drug interactions.

Monitor hepatic profile.

  • Drug interactions
  • QTc prolongation
  • Hepatic enzyme abnormalities
  • Rash - up to 20%
  • Visual disturbance
  • Fluorosis
  •  GI upset

Lots!!

  •  CYP450 interactions ++.
  •  Other QTc prolonging agents.
  •  Recommend review of pt medications due to high frequency of significant interactions.

Restricted to Infectious Diseases Providers and Oncology

Antimicrobial class: Triazole antifungal, Second generation

Pregnancy category: D

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Poor