General Spectrum of Activity
Therapy for herpesviral infections (HSV and VZV) including encephalitis.
Prophylaxis of herpesviral infections if recurrent disease or immunocompromised.
Follow SCr as appropriate.
Check urine for crystals if AKI suspected.
First Line Indications
Mycophenolate can increase the acyclovir concentration.
May diminish efficacy of zoster live or varicella vaccine.
For oral indications, valacyclovir is the pro-drug, which is more bioavailable with more convenient dosing.
Antimicrobial class: Antiviral. Nucleoside analogue.
Pregnancy category: B
Average serum half life: 3 hours
CSF penetration: Therapeutic with IV formulation
Urine penetration: Therapeutic