Antimicrobials
Acyclovir

Acyclovir

None
Moderate
Oral: $ IV:$$

Spectrum of Activity

Dosing

General Information

Therapy for herpesviral infections (HSV and VZV) including encephalitis.

Prophylaxis of herpesviral infections if recurrent disease or immunocompromised.

Follow SCr as appropriate.

Check urine for crystals if AKI suspected.

HSV encephalitis

  •  GI upset
  •  Phlebitis
  •  Increased SCr
  •  AKI from crystal nephropathy

Mycophenolate can increase the acyclovir concentration.

May diminish efficacy of zoster live or varicella vaccine.

For oral indications, valacyclovir is the pro-drug, which is more bioavailable with more convenient dosing.

Antimicrobial class: Antiviral. Nucleoside analogue.

Pregnancy category: B

Average serum half life: 3 hours

CSF penetration: Therapeutic with IV formulation

Urine penetration: Therapeutic