Antimicrobials
Meropenem

Meropenem

Restricted

High
None
$15-30/day

Dosing

General Information

Therapy of serious, often nosocomial infections involving resistant gram negative organisms.

  •  Immediate and delayed-type allergy
  •  GI disturbance
  •  Cytopenias, positive Coombs
  •  Liver enzyme abnormalities

Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold (cannot overcome this)

Restricted to Infectious Diseases (for very resistant organisms)

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic with high doses

Biliary penetration: Therapeutic