Antimicrobials
Trimethoprim-Sulfamethoxazole

Trimethoprim-Sulfamethoxazole

Low
Excellent
See Below

Dosing

General Information

  •  Urinary tract infections
  •  MRSA infections
  •  Stenotrophomonas infections
  •  Pneumocystis jirovecii pneumonia (Treatment or prophylaxis)
  •   Toxoplasmosis prophylaxis

PO: <$1/day

PO susp: $5/day

IV: $70-90/day

Follow creatinine and electrolytes in patients at increased risk renal failure, hyperkalemia.

  •  Gastrointestinal upset common
  •  Bone marrow suppression
  •  Hyperkalemia
  •  Renal failure
  •  Hepatitis
  •  Aseptic meningitis
  •  Stevens Johnson syndrome/toxic epidermal necrolysis
  •  Other rashes

ACEi - Increased serum potassium level

Methotrexate - Marrow suppression

Increases phenytoin

Increases INR with warfarin

Antimicrobial class: Sulfonamide - Antifolate

Pregnancy category: D

Average serum half life: 10 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic