General Spectrum of Activity
MSSA infections - beta lactams have better outcome data and are preferred for the treatment of MSSA
Suspected or proven MRSA, coagulase-negative Staphylococcal infections, ampicillin resistant Enterococcal infections.
Need 2 random vancomycin levels to calculate AUC. Generally draw peak 1 hour after end of infusion, draw trough 30 min before next dose and pharmacist can calculate AUC.
Changing renal function, dialysis or meningitis:
Target trough 15-20mcg/mL for most serious infections, 20-25mcg/mL for meningitis.
Aminoglycosides, ketorolac and contrast may potentiate nephrotoxicity.
Careful with concomitant nephrotoxins.
Antimicrobial class: Glycopeptide
Pregnancy category: C
Average serum half life: 8 hours
Biliary penetration: Moderate
CSF penetration: Moderate
Lung penetration: Therapeutic
Urine penetration: Therapeutic