Antimicrobials
Dexamethasone

Dexamethasone

N/A
Excellent

Dosing

General Information

Dexamethasone is a corticosteroid that has been studied as part of the RECOVERY trial, a large randomized trial based in the United Kingdom and has demonstrated²:

  • 35% reduction in mortality among mechanically ventilated patients

    • 29.0% in dexamethasone arm 40.7% in the control arm
    • RR 0.65; 95% CI, 0.51–0.82, P < 0.001
  • 20% reduction in mortality among patients with supplemental oxygen

    • 21.5% dexamethasone-treated v 25.0% in the control arm
    • RR 0.80; 95% CI, 0.70–0.92, P = 0.002
  • Hyperglycemia

  • Neuropsych effects (insomnia, irritability)

  • Heartburn

  • Impaired wound healing

  • Fluid retention