Day 2 Bundle

Empiric Therapy Reassessment

Consider other causes of fever, elevated CRP, or leukocytosis such as:

  • Normal post-operative inflammation

  • DVT / PE

  • Trauma

Can the antibiotic be narrowed based on microbiology results?

Continue and reassess at 72 hours

What duration of antibiotic therapy is needed for this patient's diagnosis?

Persistent fever despite antibiotics

Non-infectious causes, such as:

  • connective tissue diseases / autoimmune conditions

  • drug reactions

Source control / abscess that needs drainage

Drug - bug mismatch: verify sensitivities

Expected disease course, for example infective endocarditis

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