Can antibiotics be stopped because no bacterial infection?
Consider other causes of fever, elevated CRP, or leukocytosis such as:
Normal post-operative inflammation
DVT / PE
Can the antibiotic be narrowed based on microbiology results?
Can an oral antibiotic be used?
Continue and reassess at 72 hours
Determine treatment duration
Non-infectious causes, such as:
connective tissue diseases / autoimmune conditions
Source control / abscess that needs drainage
Drug - bug mismatch: verify sensitivities
Expected disease course, for example infective endocarditis