Usually NOT reversible
Cochlear:
Vestibular:
Assess for baseline impairment such as hearing deficits, balance issues, tinnitus, vertigo, etc
Baseline and serial audiograms should be ordered for patients whose therapy is anticipated to exceed 14 days or in those at high risk for toxicity
May be reversible, single dose safe in sepsis
Higher risk when used with other nephrotoxins
Rare, flaccid paralysis, respiratory muscle weakness, contraindicated in myasthenia gravis