Guidelines
Diagnostic Considerations

Diagnostic Considerations

Considerations

If Clostridioides (Clostridium) difficile Infection (CDI) is suspected, send a stool sample for testing and initiate Contact Precautions Plus (+)

Empiric therapy for CDI should be started while awaiting diagnosis if:

  • Substantial delay in laboratory confirmation is expected
  • Patient symptoms are consistent with severe CDI

Assess patient for medications or interventions that are known to cause diarrhea, such as laxative therapy and enteral feeds, etc.

Do not test stool of asymptomatic patients

  • 3%-14% carriage in adults admitted to hospital
  • Test of cure is not recommended since testing can remain positive even after successful treatment