Anaerobic spore forming gram positive bacilli, box-car shaped
Diarrhea often starts after taking antibiotics. Chemotherapy and malignancy also increase risk
Can occur in outbreaks
Recurrence is very common therefore previous history of C. difficile is a risk factor
Antacids, especially proton-pump inhibitors, may increase risk
Profuse, watery diarrhea: 3 or more bowel movements per day
Pseudomembranous colitis or toxic megacolon.
Do NOT perform test of cure, since test can remain positive even after cure