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TMP-SMX 8-12 mg/kg/day (TMP component) IV/PO divided q8-12h (consider maximum dose of 960 mg TMP component per day).
Consider combination therapy with the addition of a second agent (minocycline [preferred], tigecycline, levofloxacin, or cefiderocol) if there is a delay in clinical improvement with TMP-SMX alone or severe infection.
If susceptible to Levofloxacin, should not be used as a single agent.
Do NOT use ceftazidime (even if reported as susceptible).
Aerobic non-fermenting gram negative rod
Most common reason for isolation is colonization of the respiratory tract.
Most common true infections:
May require contact precautions.
True pneumonia more likely in ICU and oncology patients, those with advanced age and after/during treatment with broad spectrum antimicrobial use.