TMP-SMX 8-12 mg/kg/day (TMP component) IV/PO divided q8-12h (consider maximum dose of 960 mg TMP component per day).
- For weight ~70kg: 15 mL IV q8h or 1-2 DS tabs TID
- 1 mL = 16 mg TMP
- 1 DS tab = 160 mg TMP
Consider combination therapy with the addition of a second agent (minocycline [preferred], tigecycline, levofloxacin, or cefiderocol) if there is a delay in clinical improvement with TMP-SMX alone or severe infection.