Cefuroxime

C difficile risk
Medium
Oral Bioavailability
Moderate
Cost
IV$15/d PO $0.60/d

Dosing

IVPO750 - 1500 mg IV q8h

  • Use higher dosing range for serious/invasive infections500 mg PO q12h

CrCl > 30 mL/minCrCl 10 - 30 mL/minCrCl < 10 mL/minNo renal adjustment required750 - 1500 mg IV q12h750 - 1500 mg IV q24h

CrCl > 30 mL/minCrCl 10 - 30 mL/minCrCl < 10 mL/minNo renal adjustment required500 mg PO q24h500 mg PO q48h

IVPO750 - 1500 mg IV q24h

  • Give dose after dialysis on HD days500 mg PO q24h

  • Give dose after dialysis on HD days

IVPO750 - 1500 mg IV q24h500 mg PO q24h

IVPONo data, consider 750 - 1500 mg IV q8-12hNo data for PO dosing

General Information

  • Community acquired pneumonia

  • Epiglottitis

  • Cytopenias

  • GI upset

  • Diarrhea

  • Abnormal liver enzymes

No significant interactions.

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic

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