May be used in place of ceftriaxone for patients with biliary sludging or cholestatic hepatitis.
EMPIRIC therapy of severely ill patients with suspected Gram-negative infection
Documented Gram-negative infection resistant to 1st and 2nd generation cephalosporins
Meningitis
Spontaneous bacterial peritonitis, community-acquired secondary peritonitis (or hospital acquired with no previous antimicrobial therapy), or intra-abdominal abscess.
Community acquired pneumonia
Does not cover Pseudomonas and other resistant Gram-negatives, ESBLs or AmpC producing Enterobacteriaceae
Potential link to seizure risk
Prefer ceftriaxone for CNS infection in renal failure
Antimicrobial class: 3rd Generation Cephalosporin
Pregnancy category: B
Average serum half life: 1.5 hours
Biliary penetration: Moderate
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic