C difficile risk
Oral Bioavailability


500 - 1000 mg PO q8h

500 mg PO q12h

1000 mg PO q8h

CrCl > 30 mL/minCrCl 10 - 30 mL/minCrCl < 10 mL/minNo renal adjustment required500 mg PO q12h500 mg PO q24h

500 mg PO q24h

  • Give dose after dialysis on HD days

500 mg PO q12h

No data, consider 500 mg PO q12h

General Information

  • Treatment of infections due to beta-hemolytic streptococcus (Streptococci group A/B/C/G) such as skin infections, pharyngitis

  • Community acquired pneumonia

  • Acute exacerbation of COPD

  • Bacterial sinusitis

  • Dental infections or prophylaxis prior to dental procedures when indicated

  • Enterococcus faecalis infections

  • Allergy/rash (immediate or delayed), especially in setting of mononucleosis infection

  • Cytopenias

Allopurinol - increased risk of rash

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

CNS penetration: Insufficient data

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