Spectrum Of Activity
- Use adjusted BW in obesity
IVPO5 mg/kg IV q8h400 mg PO 5 x /day
10-15 mg/kg IV q8h
800 mg PO 5 x /day
CrCl > 50 mL/minCrCl 30 - 50 mL/minCrCl 10 - 30 mL/minCrCl < 10 mL/minNo renal adjustment required100% of indicated dose IV q12h100% of indicated dose IV q24h50% of indicated dose IV q24h
CrCl > 30 mL/minCrCl 10 - 30 mL/minCrCl < 10 mL/minNo renal adjustment required400 mg PO TID400 mg PO BID
IVPO (Most Indications)50% of indicated dose IV q24h
- Give dose after dialysis on HD days400 mg PO BID
IVPO (Most Indications)50% of indicated dose IV q24h400 mg PO BID
IVPO (Most Indications)50% of indicated dose IV q12hNo Data - use IV
Therapy for herpes viral infections (HSV and VZV) including encephalitis. Not for CMV (cytomegalovirus)
Prophylaxis of herpes viral infections if recurrent disease or immunocompromised.
Follow serum creatinine and monitor for neurotoxicity.
Phlebitis with IV
Increased creatinine from crystal nephropathy; pre-hydration may limit kidney injury
Neurotoxicity: hallucinations, delusions, involuntary movements
Mycophenolate can increase acyclovir concentration
May diminish efficacy of zoster or varicella vaccine
For oral indications, valacyclovir is the pro-drug, which is more bioavailable with more convenient dosing.
Antimicrobial class: Antiviral. Nucleoside analogue.
Pregnancy category: B
Average serum half life: 3 hours
CSF penetration: Therapeutic (IV only)