Primary: Polymicrobial infections with no other oral therapeutic options either alone or in combination
Infections with microorganisms resistant to first line agents.
Bite prophylaxis (when indicated) or bite infections.
For prolonged therapy, monitor liver enzymes and function.
Cytopenias
Diarrhea (less likely with twice daily dosing regimen)
C. difficile
Hepatotoxicity due to clavulanate - usually mild, liver failure is very rare.
Increased risk of rash with allopurinol
amoxicillin-clavulanate: 875-125 mg, 500-125 mg, and 250-125 mg tablets
Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor
Pregnancy category: B
Average serum half life: 1 hour
Biliary penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic
CSF penetration: Insufficient data