Antimicrobials
Amoxicillin-Clavulanate Oral

Amoxicillin-Clavulanate Oral

High
Excellent
$

General Information

  • Primary: Polymicrobial infections with no other oral therapeutic options either alone or in combination

  • Infections with microorganisms resistant to first line agents.

  • Bite prophylaxis (when indicated) or bite infections.

For prolonged therapy, monitor liver enzymes and function.

  • Cytopenias

  • Diarrhea (less likely with twice daily dosing regimen)

  • C. difficile

  • Hepatotoxicity due to clavulanate - usually mild, liver failure is very rare.

Increased risk of rash with allopurinol

amoxicillin-clavulanate: 875-125 mg, 500-125 mg, and 250-125 mg tablets

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

CSF penetration: Insufficient data