Spectrum Of Activity
Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility.
Associated with more treatment failures than alternatives and excess mortality - Only use when alternatives are not suitable
Pseudomonas and Proteus vulgaris are inherently resistant
Avoid or use with caution in patients with tetracycline reactions.
GI side effects very prominent with significant nausea and vomiting.
Tetracycline related adverse events: photosensitivity, acute pancreatitis.
Increased liver enzymes.
Documented safety concerns in bacteremia, only use if no other options
Antimicrobial class: Tetracycline derivative
Pregnancy category: D
Average serum half life: 42 hours
Biliary penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Insufficient data