Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility.
Associated with more treatment failures than alternatives and excess mortality - Only use when alternatives are not suitable
Pseudomonas and Proteus vulgaris are inherently resistant
Oral contraceptives
Documented safety concerns in bacteremia, only use if no other options
Antimicrobial class: Tetracycline derivative
Pregnancy category: D
Average serum half life: 42 hours
Biliary penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Insufficient data