Spectrum Of Activity
- Nephrotoxicity: more likely if trough levels persistently 15-20 mg/L
- Cytopenias especially neutropenia and thrombocytopenia
- Ototoxicity with prolonged use
- Histamine-release causes a vancomycin flushing reaction
Aminoglycosides may potentiate nephrotoxicity.
May enhance neuromuscular blockade of NM blocking agents.
Careful with concomitant nephrotoxins.
Oral vancomycin administration is suitable only for C. difficile infection as it is not absorbed beyond the GI tract. Do not use oral vancomycin as stepdown therapy for IV vancomycin
Vancomycin is a less effective choice than a beta-lactam antimicrobial for methicillin-susceptible staphylococcal infections
Staphylococcus aureus with an MIC of greater than or equal to 2 mg/L have a high failure rate; consider an ID consult
Antimicrobial class: Glycopeptide
Pregnancy category: C
Average serum half life: 8 hours
Biliary penetration: Moderate
CSF penetration: Moderate
Lung penetration: Therapeutic
Urine penetration: Therapeutic