Spectrum Of Activity
Vancomycin-resistant Enterococcus (VRE) infections when daptomycin cannot be used
MRSA infections in which vancomycin or daptomycin cannot be used
Inhibits monoamine oxidase. Risk of serotonin syndrome if given to patients taking SSRIs, serotonin norepinephrine reuptake inhibitors or MAOI – check for drug interactions
Predictable cytopenia after 2 weeks of therapy: monitor CBC at least once a week
Lactic acidosis, peripheral neuropathy, optic neuropathy after 4 weeks of therapy
Visual testing for therapy >3 months or if symptoms develop on therapy.
Elevated liver enzymes
Myelosuppression (usually with >2weeks therapy)- reversible
Peripheral/optic neuropathy with prolonged courses
SSRI and other serotonergics/MAOIs - Increased risk of serotonin syndrome.
Rifampin decreases linezolid levels.
Excellent oral bioavailability (100%)
Antimicrobial class: Oxazolidinone
Pregnancy category: C
Average serum half life: 5 hours
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic