Amphotericin B Deoxycholate
Spectrum Of Activity
Primarily used for compounding
Preferred over other amphotericin formulations for neonates. See IWK Spectrum App
Frequency depends on course, but daily reasonable during initiation
Infusion related symptoms
Electrolyte abnormalities -
HypoK and HypoMg
Loss of bicarb
See "Additional Information"
Main concern is concomitant nephrotoxins. Use should be minimized during amphotericin therapy.
Increased digoxin toxicity with hypokalemia.
Premedication with acetaminophen, diphenhydramine or hydrocortisone are used. Meperidine may be used for rigors.
Pay careful attention to electrolyte and fluid status with boluses (usually 500mL) of NS before and after infusion, as well as K and Mg supplementation PRN.
Antimicrobial class: Antifungal. Polyene
Pregnancy category: B
Average serum half life: 24 hours
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic