Fosfomycin

C difficile risk
Low
Oral Bioavailability
Moderate
Cost
$11/3g

Dosing

Defined criteria for use and/or important safety considerations. See below for more information.

3 g PO x 1 dose

3 g PO q72h x 2-3 doses

CrCl > 30 mL/minCrCl < 30 mL/minNo renal adjustment requiredNo data, if used: single dose only

No data, if used: single dose only

General Information

Acute cystitis

Upper urinary infection (pyelonephritis or renal abscess) or systemic infections (bacteremia)

  • GI upset, especially diarrhea

  • Headache

  • Eosinophilia, neutropenia

  • Hypokalemia

No significant interactions

  • Laboratory sensitivity testing available upon request

Antimicrobial class: Phosphonic acid derivative

Pregnancy category: B

Average serum half life: 6 hours

Urine penetration: Therapeutic

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