Oseltamivir

C difficile risk
None
Oral Bioavailability
Excellent
Cost
$3/day

Dosing

Defined criteria for use and/or important safety considerations. See below for more information.

75 mg PO BID

CrCl > 60 mL/minCrCl 30 - 60 mL/minCrCl 10 - 30 mL/minCrCl < 10 mL/minNo renal adjustment required30 mg PO BID30 mg PO daily75 mg PO x 1 dose

75 mg PO qHD

  • Give dose after dialysis on HD days; none on non-HD days

30 mg PO x 1 dose

30 mg PO daily

General Information

Non-hospitalized patients at low risk of complications, particularly if symptoms > 2days

Treatment and prophylaxis of influenza

  • GI upset

  • Rare - Stevens Johnson

  • Neuropsychiatric side effects reported

No evidence for 150 mg BID dosing

Used for prophylaxis in specific situations, on the guidance of public health or infection prevention and control

Antimicrobial class: Antiviral - Neuraminidase inhibitor

Pregnancy category: C

Average serum half life: 2 hours

Lung penetration: Therapeutic

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