Nitrofurantoin

C difficile risk
Low
Oral Bioavailability
Excellent
Cost
$1/day

Dosing

100 mg PO BID (macrocrystals)

CrCl > 30 mL/minCrCl < 30 mL/minNo renal adjustment requiredAvoid

Avoid

General Information

First line treatment for uncomplicated urinary tract infections

Pyelonephritis or other systemic infections

  • Interstitial pneumonitis and fibrosis especially with prolonged use.

  • Peripheral neuropathy

Antacids decrease absorption

Antimicrobial class: Nitrofuran

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: None

Lung penetration: None

Urine penetration: Therapeutic

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