Doxycycline

C difficile risk
Low
Oral Bioavailability
Excellent
Cost
$0.40/day

Dosing

100 mg PO q12h

No renal adjustment required

General Information

  • Lyme Disease

  • Community Acquired Pneumonia

  • Non-invasive Methicillin resistant Staphylococcus aureus infections

  • GI upset and erosive esophagitis: take with food but not with dairy

  • Photosensitivity rash

  • Teeth staining

  • Erosive esophagitis (drink plenty of water with dose)

  • Divalent cations - decreased absorption therefore recommend to space by 2 hours

  • Increased digoxin levels

  • Increased INR with warfarin

  • Take with food to reduce GI upset

  • Avoid iron, magnesium, calcium for at least 2 hours before or 2 hours after doxycycline administration

  • Please refer to IWK Spectrum for pregnancy or pediatric recommendations

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 18 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic

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