Antimicrobials
Levofloxacin

Levofloxacin

High
Excellent
IV $$ PO $

General Information

Primary - Community Acquired Pneumonia (CAP) requiring ICU admission, Legionella infections

Do not use as monotherapy for Stenotrophomonas

Monitor QTc in patients with increased risk

  • QTc prolongation

  • Dysglycemia

  • Rash

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • CNS toxicity including confusion, psychosis

  • Other QTc prolonging agents

  • Divalent cations - Decreased absorption

  • Warfarin - Increased INR

  • Avoid dairy products, antacids, and other sources of divalent cations (Ca, Fe, Mg, Al, Zn) which can chelate levofloxacin and prevent absorption
  • Must hold continuous tube feeding 2 h before and 2 h after administration

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 7 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Therapeutic

CSF penetration: Insufficient data