Antimicrobials
Fluconazole

Fluconazole

Low
Excellent
IV $$ PO $

Dosing

General Information

  • Candida infections both muccocutaneous and invasive (ie. Candidemia)

  • Cryptococcus and Coccidioides infections

Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement. Consider liver enzyme monitoring

  • Drug interactions

  • QTc prolongation

  • Hepatic enzyme abnormalities

  • Rash

  • Alopecia

  • GI upset

  • Many via CYP450. Suggest review specific patient medications.

  • Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics.

  • Risk when combining with other QTc prolonging medications.

Antimicrobial class: Triazole antifungal

Pregnancy category: C

Average serum half life: 20 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic