Cloxacillin

C difficile risk
Medium
Oral Bioavailability
None
Cost
$23/day

Dosing

2 g IV q4h

No renal adjustment required

General Information

  • Treatment of invasive MSSA and Streptococci group A/B/C/G infections

  • Preferred over cefazolin if require CNS penetration

  • Cytopenias

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Phlebitis at injection site in a peripheral vein

  • Can increase methotrexate levels.

  • Decrease mycophenolate levels.

  • Tetracyclines can diminish cloxacillin activity.

Antimicrobial class: Antistaphylococcal Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic

CSF penetration: Therapeutic

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