Cefepime

C difficile risk
High
Oral Bioavailability
N/A
Cost
$85/day

Dosing

Requires AMS review within 72 hours. See below for more information.

See IWK Spectrum app

General Information

Febrile neutropenia in pediatrics: 1) With penicillin allergy or 2) Receiving methotrexate

Need to add metronidazole if worry of anaerobic infection

  • Thrombocytopenia, neutropenia

  • Non-convulsive status epilepticus

  • Transient liver function test increase

  • Diarrhea

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate

Route of Elimination: Renal clearance (60% unchanged)

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