Ciprofloxacin - Renal Dosing

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

CrCl > 30 mL/min

No renal adjustment required

CrCl 10 - 30 mL/min

400 mg IV q24h

  • CNS and Pseudomonas infection: 400 mg IV q12h

CrCl < 10 mL/min

400 mg IV q24h

CrCl > 30 mL/min

No renal adjustment required

CrCl < 30 mL/min

500 - 750 mg PO q24h

IV

400 mg IV q24h

  • Give dose after dialysis on HD days

PO

500 - 750 mg PO q24h

  • Give dose after dialysis on HD days

IV

400 mg IV q24h

PO

500 - 750 mg PO q24h

IV

400 mg IV q12h

PO

500 - 750 mg PO q12h

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