Amphotericin B - Liposomal (AmBisome)
Spectrum Of Activity
Defined criteria for use and/or important safety considerations. See below for more information.
Use total body weight
Suggest maximum dosing weight of 100 kg
Contact Pharmacy for dosing and pre-medication
AmBisome 3 - 5 mg/kg IV q24h infused over several hours
- Contact Pharmacy for dosing
Alternative indication(s): An option for invasive Candida infections, but an echinocandin, fluconazole, or voriconazole is usually preferred.
Frequency depends on course, but daily reasonable during initiation
Same toxicities as conventional Amphotericin B but with less frequency.
Infusion related symptoms
HypoK and HypoMg
Loss of bicarb
See additional information
Main concern is concomitant nephrotoxins. Use should be minimized during amphotericin therapy.
Increased digoxin toxicity with hypokalemia.
Lipid associated AmB is taken up preferentially by phagocytic cells and concentrated at sites of infection while minimizing renal exposure.
Pay careful attention to electrolyte and fluid status with boluses (usually 500mL) before and after infusion, as well as K and Mg supplementation PRN.
Antimicrobial class: Antifungal. Polyene. Lipid formulations designed to minimize toxicity.
Average serum half life: 150 hours
Biliary penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Poor
CSF penetration: Insufficient data