For use in combination for treatment of Group A streptococcus (Streptococcus pyogenes) or Staphylococcus aureus infections causing toxic shock syndrome or necrotizing fasciitis
Alternative
Noninvasive MRSA infections, if susceptible, without alternative option such as TMP/SMX or doxycycline
Part of combination therapy for Pneumocystis, Toxoplasma
Increasing resistance of Bacteroides, metronidazole is the drug of choice in such infections
Due to high rates of C. difficile with clindamycin use, clindamycin is not recommended for treatment of infections other than those associated with toxic shock syndrome