Spectrum Of Activity
Defined criteria for use and/or important safety considerations. See below for more information.
Caution should be used in patients with renal impairmentCrCl < 10Hemodialysis4 mg/kg IV once daily x 21 days4 mg/kg IV q24-36h4 mg/kg IV q48h (give dialysis day dose after dialysis)
300 mg in 6 mL sterile water by aerosol every 4 weeks. Administered by Respiratory Therapy in negative pressure room.
Alternative option to first line therapies for:
IV formulation: treatment of Pneumocystis pneumonia (Pneumocystis jirovecii)
Aerosolized: prophylaxis of Pneumocystis pneumonia (Pneumocystis jirovecii)
- Infusion: CBC, electrolytes, extended electrolytes, creatinine, liver enzymes, glucose, QTC, BP during and after IV infusion
Parenteral: electrolyte abnormalities, cytopenia, renal injury, QTC prolongation, pancreatitis, hypotension (rapid administration)
Inhaled: bronchospasm/cough, especially in patients with a smoking or asthma history (an inhaled bronchodilator prior to pentamidine may ameliorate symptoms). Dizziness and fatigue.