Imipenem-Cilastatin

C difficile risk
Medium
Oral Bioavailability
N/A
Cost
$36/day

Dosing

Requires AMS review within 72 hours. See below for more information.

  • Dosed on imipenem content

500 mg IV q6h

CrCl > 50 mL/minCrCl 30 - 50 mL/minCrCl 10 - 30 mL/minCrCl < 10 mL/minNo renal adjustment required500 mg IV q8h500 mg IV q12h

  • Meropenem preferred 250 - 500 mg IV q12h

  • Meropenem preferred

250 - 500 mg IV q12h

  • Give dose after dialysis on HD days

  • Meropenem preferred

250 - 500 mg IV q12h

  • Meropenem preferred

500 mg IV q6 - 8h

  • Meropenem preferred

General Information

  • Meropenem should usually be used instead.

  • However, imipenem can be used in situations in which broad spectrum coverage is required including Enterococcus faecalis (ampicillin susceptible) coverage.

  • Stenotrophomonas, MRSA, Enterococcus faecium, or VRE

  • Atypical infections like Legionella

Seizure risk

Seizure risk

CSF penetration: Meropenem preferred

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