Trimethoprim

C difficile risk
Low
Oral Bioavailability
N/A

Dosing

Defined criteria for use and/or important safety considerations. See below for more information.

100 mg PO BID

CrCl > 30 mL/minCrCl < 30 mL/minNo renal adjustment required100 mg PO daily

100 mg PO daily

  • Give dose after dialysis on HD days

100 mg PO daily

No data

General Information

  • Urinary Tract Infections

  • Can be used in sulfonamide-allergic or sulfonamide-intolerant patients

  • Enterococci are resistant (even if reported as sensitive)

  • S. aureus bacteremia (see S. aureus handbook page)

  • Renal injury and hyperkalemia, particularly in older patients (65 or older)

  • Regular monitoring of kidney function and electrolytes if prolonged use, over age 65, use of ACEi, ARB, or K-sparing diuretic, baseline renal injury, or other risks for AKI/hyperkalemia

  • Renal injury and hyperkalemia, particularly in older patients (65 or older)

  • Sudden cardiac death - Higher risk in patients on angiotensin converting enzyme inhibitor (ACEi), angiotensin receptor blocker (ARB), K sparing diuretic (e.g. spironolactone)

  • Aseptic meningitis is rare

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