Defined criteria for use and/or important safety considerations. See below for more information.

100 mg PO daily

100 mg PO daily can be used in combination with trimethoprim if not acutely ill

General Information

Primary indication

  • Prophylaxis for Pneumocystis jirovecii

  • Can be used for treatment in combination with trimethoprim for non-acutely ill patients

Toxoplasma gondii prophylaxis in combination with pyrimethamine and leucovorin

May be used for non-infectious diseases, ex:

  • Dermatitis herpetiformis

  • Immune thrombocytopenia (ITP)

  • Check G6PD levels prior to initiation

  • CBC (weekly for first month, monthly for 6 months and semiannually thereafter)

  • Use with caution in patients with severe anemia

  • Reticulocyte counts, liver function tests (baseline and periodic)

  • Hemolysis (dose related), enhanced in G6PD-deficient patients

  • Methemoglobinemia (dose-related; cyanosis, headache, dyspnea, chest pain, and fatigue)

  • Dapsone hypersensitivity syndrome (fever, rash, eosinophilia, lymphadenopathy, hepatitis, pneumonitis)

  • Agranulocytosis, anemia, leukopenia, pure red cell aplasia

  • Neuropathy

Discontinue therapy if a significant reduction in leukocytes, platelets, or hemopoiesis

Sulfonamide Allergy Use with caution in patients with hypersensitivity to other sulfonamides. Cross-reactions occur in only 7%–22% of sulfa-allergic patients

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