Ceftolozane-Tazobactam
Renal

Renal

Non-Dialysis (Most Indications)

CrCl greater than 50 mL/min

No renal adjustment required

CrCl 30 - 50 mL/min

750 mg IV q8h

CrCl less than 30 mL/min

375 mg IV q8h

Non-Dialysis (Pulmonary Infections)

CrCl greater than 50 mL/min

No renal adjustment required

CrCl 30 - 50 mL/min

1.5 g IV q8h

CrCl less than 30 mL/min

750 mg IV q8h

Intermittent Dialysis

Most Indications

750 mg IV x 1, then 150 mg IV q8h

  • Give dose after dialysis on HD days
Pulmonary Indications

2.25 g IV x 1, then 450 mg IV q8h

  • Give dose after dialysis on HD days

Peritoneal Dialysis and Continuous Renal Replacement Therapy (CRRT)

No data