Use is contraindicated in CrCl< 40-60 mL/min. Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing
Uncomplicated cystitis in patients with normal renal function.
Does not provide adequate renal concentrations for treatment of systemic infections (i.e urosepsis, pyelonephritis); appropriate for cystitis and/or urinary prophylaxis.
Monitor liver and renal function and pulmonary function (with long term use). CBC for hemolytic anemia.
Nausea (decreased if taken with food)
Hemolytic anemia if G6PD-deficient
Peripheral neuropathy
Interstitial pneumonitis and fibrosis with prolonged use (> 6 months)
Concentration: 10 mg/mL (compounded) Taste: palatable Not all strengths of oral liquids are listed nor are available on IWK formulary
50 mg tablet 100 mg capsule Nitrofurantoin Monohydrate Macrocrystals (MacroBID®)
Tablets and capsules are preferred especially over an unpleasant tasting liquid. Not all strengths of oral tablets/capsules are listed and they are not all available on the IWK formulary
Does not provide adequate renal concentrations for treatment of systemic infections (i.e urosepsis, pyelonephritis); appropriate for cystitis and/or urinary prophylaxis.
Reduce dose in renal impairment or need for caution.
Contraindicated in infants less than 1 month of age (risk of hemolytic anemia), moderate-severe renal impairment, G-6-PD deficiency.
Do not use near term in pregnancy.
Antimicrobial class: Nitrofuran
Average serum half life: No pediatric data. Adults: 20 to 60 minutes and is prolonged with renal impairment
Route of Elimination: As metabolites and unchanged drug (40%) in the urine and small amounts in the bile; renal excretion is via glomerular filtration and tubular secretion
