Concentration: (Per 1 mL) Trimethoprim 8 mg and Sulfamethoxazole 40 mg (Only available via Special Access Program with Health Canada)
Taste: Very palatable
Not all strengths of oral liquids are listed nor are available on IWK formulary
Pediatric Tablet: Trimethoprim 20 mg and Sulfamethoxazole 100 mg
Adult Tablet: Trimethoprim 80 mg and Sulfamethoxazole 400 mg
Double Strength Tablet: Trimethoprim 160 mg and Sulfamethoxazole 800 mg
Tablets and capsules are preferred especially over an unpleasant tasting liquid. Not all strengths of oral tablets/capsules are listed and they are not all available on the IWK formulary.
Dosing is based on the trimethoprim (TMP) component
Pediatric strength tablets:100mg SMX/ 20 mg TMP
Regular strength tablets: 400mg SMX/ 80 mg TMP
Double strength tablets: 800 mg SMX/ 160 mg TMP
Suspension: (per 1 mL): 40 mg SMX/8 mg TMP
Injection: (per 1 mL): 80 mg SMX/16 mg TMP
Antimicrobial class: Sulfonamide - Antifolate
Average serum half life: TMP (prolonged in renal failure)
SMX: 9-12 hours, prolonged in renal failure (Adult data)
Route of Elimination: Both excreted in urine as metabolites and unchanged drug