Antimicrobials
ceFAZolin

ceFAZolin

C difficile risk
Medium
Oral Bioavailability
N/A
Cost
$5/day

Dosing

25 mg/kg/dose IV q12h

Post natal age 0 to 7 daysPost natal age greater than or equal to 8 days25 mg/kg/dose IV q12h 25 mg/kg/dose IV q8h

Post natal age 0 to 7 daysPost natal age greater than or equal to 8 days30 mg/kg/dose IV q12h30 mg/kg/dose IV q8h

1-2 g IV q8h (may need higher dosing i.e. 3 g in obesity)

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

  • Skin and soft tissue infection (i.e. cellulitis).

  • Surgical prophylaxis.

  • Susceptible Staphylococcal, Streptococcal and Gram negative infections.

  • Allergy (immediate or delayed). Cross allergenicty unlikely with other B-lactams

  • Can cause positive Coombs, cytopenias

Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin for the treatment of cellulitis

Antimicrobial class: 1st Generation Cephalosporin

Average serum half life: Neonates: 3-5 hours Adults: 1.8 hours

Route of Elimination: excreted unchanged in urine