ESBL- Extended Spectrum Beta-Lactamase producing organisms

ESBL- Extended Spectrum Beta-Lactamase producing organisms


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General Information

Gram negative organisms with enzymes that confer resistance to 3rd generation cephalosporins in addition to lower order beta-lactams.

Generally, normal GI flora that have a plasmid encoding ESBL.

Community-acquired and nosocomial infections occur, especially if received antimicrobials or have travelled to areas of high prevalence (i.e. Asia/India).

Human-to-human transmission occurs and outbreaks have beed described.

Can also pick up from environment/water, surfaces, animals, and meat!

Asymptomatic colonization, or any syndrome caused by the organism carrying it (see the organism for list)

ESBLs vs. ampC: Most ESBLs are plasmid-encoded, whereas ampCs are usually inducible and chromosomal.

In the lab, ESBLs test susceptible to cefoxitin and cefotetan, and are inhibited by beta-lactamse inhibitors such as tazobactam.

They test resistant to aztreonam.