Spectrum of Activity

General Information

Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility

Associated with more treatment failures than alternatives and excess mortality - Black Box Warning

Nausea, vomiting.

Tetracycline related adverse events: photosensitivity, acute pancreatitis, increased BUN, acidosis, hypophosphatemia, rash (can be severe), abnormal hepatic enzymes and/or function tests.

Permanent tooth discoloration in children < 8 years old.

Recommended Infectious Disease consult.

Documented safety concerns (increaed mortality in adult studies).

Antimicrobial class: Tetracycline derivative

Average serum half life: No pediatric data. Adults: Single dose: 27 hours; Multiple doses: 42 hours

Route of Elimination: 22% excreted in urine as unchanged drug; 59% in feces, primarily as unchanged drug

Clearance: Reduced by 25% in patient with moderate hepatic impairment and 55% in severe hepatic impairment