Uncomplicated cystitis in patients with normal renal function
Interstitial pneumonitis and fibrosis esp. with prolonged use
Peripheral neuropathy
Does not provide adequate renal concentrations for treatment of systemic infections (i.e urosepsis, pyelonephritis); appropriate for cystitis and/or urinary prophylaxis.
Antimicrobial class: Nitrofuran
Average serum half life: No pediatric data. Adults: 20 to 60 minutes and is prolonged with renal impairment
Route of Elimination: As metabolites and unchanged drug (40%) in the urine and small amounts in the bile; renal excretion is via glomerular filtration and tubular secretion